multiple transitions within a narrow temperature range must be separated) Email: application.india@perkinelmer.com Analytical results DSC analysis was carried out on a pharmaceutical sample in nitrogen atmosphere. 0000008427 00000 n For instance, McGregor at al13 used FS-DSC to https : Theoretically, almost any substance whether solid, semi-solid or liquid can be analyzed and characterized with thermal analytical techniques. DSC 3500 Sirius The DSC 3500 Sirius combines compactness, robustness and ease-of-use with high detection sensitivity, thus offering optimal conditions for quality assurance and failure analysis in areas such as foods, cosmetics, polymers, technical textiles, and organic and inorganic materials. * Pans of Al, Cu, Au, Pt, alumina, and graphite are available and need to be chosen to avoid reactions with samples and with regard to the temperature range of the measurement. This is Thermal analysis equipment can be found in many analytical, development, formulation and QC laboratories. 0000012191 00000 n DSC instruments are available in a range of sensitivities for robust screening and quality control applications. (2,3) In these experiments, molecules change from one conformation to another. the course of the chapter, further texts in which more information on specific subjects 0000002804 00000 n On that basis, the discussion has been confined to the most widespread uses of DSC within the pharmaceutical sciences, namely polymorphism, pharmaceutical hydrates, and glassy systems. 0000020475 00000 n to detect weak transitions), a low heating rate improves resolution (e.g. 0000001344 00000 n 10 39 Figure 1 shows the DSC thermograms for the sample. 0000014160 00000 n During First, the book by Ford and Timmins Differential Scanning Calorimetry Instrument• Two basic types of DSC instruments: power compensation DSC and heat-flux DSC Power compensation DSC Heat flux DSC 10. provide a comprehensive account of a selection of the topics covered here. Application of Ion Chromatography in Pharmaceutical and Drug Analysis August 2011 Journal of chromatographic science 49(7):524-39 DOI: … 0000001076 00000 n 0000071601 00000 n Practical Applications of HyperDSC in a Pharmaceutical Laboratory HyperDSC™(or High Speed DSC), a thermal technique that complements conventional calorimetry, has found applications in the fields of pharmaceutical, polymers and compounds. xref Freeze-drying of protein pharmaceuticals: The application of thermal analysis November 2004 Cryo letters 25(6):389-404 Source PubMed Authors: Vicky L … Application of XRD-DSC system to the optimization of manufacturing process for the freeze-dried pharmaceuticals. is available will also be recommended. Dexamethasone acetate finds use as an anti-inflammatory agent. a description of many of the pharmaceutical systems not covered in this chapter, the Registered in England & Wales No. DSC is also used to determine the heat of fusion, purity, polymorphism, the glass transition, and oxidation stability. 0000002936 00000 n an extremely large topic in its own right, and it is not logistically feasible to list, every study that could be placed in this category. Find out in the following why this technique is that frequently used. Paul Gabbott is Director, Thermal Instruments Ltd, based in Beaconsfield, UK and has over 25 years experience working with PerkinElmer Ltd in the field of thermal … DOI link for Thermal Analysis of Pharmaceuticals, In this chapter, some of the considerations relating to the use of differential scanning 0000001558 00000 n reader is referred to the following general texts. 0000010370 00000 n 0000000016 00000 n Initially, two types of DSC instruments were available - heat-flux DSC (hf-DSC) and power compensation DSC (pc-DSC). DSC has found its application in food sciences, pharmaceuticals, polymer industry, ceramics, and many other fields. The main applications of TGA are evaporation, desorption and vaporization behavior, thermal stability, decomposition kinetics, and the analysis of composition. Because FS-DSC can be used to inhibit kinetically limited phase changes such as crystallisation, it has found wide application to polymorphic characterisation of pharmaceuticals. 0000047492 00000 n Common materials include foods, pharmaceuticals, electronic materials, polymers, ceramics, organic and inorganic compounds, even biological organisms… This is the case, for example, with emulsions, which often change their consistency even at summary temperatures while separating into … The DSC 404 F1 Pegasus ® and DSC 404 F3 Pegasus ® are two versions for the precise determination of specific heat and caloric effects, particularly in the high-temperature range. Power Compensation DSC individual heaters controller ∆Pintroduced in the early 1960s. been confined to the most widespread uses of DSC within the pharmaceutical %%EOF A fast heating rate increases sensitivity (e.g. 0000047193 00000 n For ursodeoxycholic acid, the results confirmed that the influence of milling on crystallinity is dependent on milling time. 0000047900 00000 n The current field of thermal analysis is both diverse and dynamic. DSC, alone or in combination with hot-stage microscopy, is able to differentiate between different polymorphic structures and, … We have access to a higher temperature DSC/DTA instrument capable of a maximum temperature of 1500 C, though it has a lower sensitivity at temperatures below 725 C compared to our primary DSC. 0000001937 00000 n The difference in rate of heat flow into the sample and a reference material chemist DSC...: DSC application of dsc in pharmaceuticals used to determine the heat of fusion, purity,,... 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